Eaton-Peabody Laboratories
Massachusetts Eye and Ear / Harvard Medical School
Cortical plasticity and gain control following cochlear injury
Papers (8)
Cortical PV interneurons regulate loudness perception and sustainably reverse loudness hypersensitivity.
Neuron · 2026
40 Hz stimulation of cortical PV interneurons durably reverses loudness hypersensitivity in mice.
Cochlear neural degeneration disrupts hearing in background noise by increasing auditory cortex internal noise.
Neuron · 2021
Cochlear neural degeneration drives PV-linked cortical hyperactivity that predicts hearing-in-noise failures.
Fast-spiking GABA circuit dynamics in the auditory cortex predict recovery of sensory processing following peripheral nerve damage.
eLife · 2017
Homeostatic dynamics of PV-mediated cortical inhibition in the first days after auditory-nerve damage predict how well sound processing recovers.
Central Gain Restores Auditory Processing following Near-Complete Cochlear Denervation.
Neuron · 2016
After near-complete cochlear denervation, the cortex ramps up 'central gain' to restore basic sound detection, compensation that can overshoot into hyperactivity.
Adding insult to injury: cochlear nerve degeneration after "temporary" noise-induced hearing loss.
The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009
The seminal finding: a 'temporary' noise-induced threshold shift that fully recovers still leaves permanent, silent damage, acute loss of nerve terminals and delayed degeneration of the cochlear nerve.
Cochlear neuropathy in human presbycusis: Confocal analysis of hidden hearing loss in post-mortem tissue.
Hearing research · 2015
Human evidence: post-mortem temporal bones from older adults with near-normal hair cell counts still showed cochlear nerve fiber loss, synaptopathy in human aging, not just mice.
Cochlear synaptopathy in acquired sensorineural hearing loss: Manifestations and mechanisms.
Hearing research · 2017
Review: well before hair cells die and thresholds rise, noise and aging silently sever the synapses between inner hair cells and the auditory nerve.
A National Cohort Study of Tinnitus and Hearing Loss in the Million Veteran Program.
Ear and hearing · 2026
National VA cohort of 267,395 veterans finds tinnitus in 47%, more common with traumatic brain injury, anxiety, or depression, and with earlier/steeper hearing loss than a civilian cohort.