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JR
Jennifer Resnik
Eaton-Peabody Laboratories
Dynamics of cortical inhibitory (PV) circuits and central gain after auditory-nerve damage.
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Laboratory1
Hypotheses2
Papers (3)
Cochlear neural degeneration disrupts hearing in background noise by increasing auditory cortex internal noise.
Neuron · 2021
Cochlear neural degeneration drives PV-linked cortical hyperactivity that predicts hearing-in-noise failures.
Fast-spiking GABA circuit dynamics in the auditory cortex predict recovery of sensory processing following peripheral nerve damage.
eLife · 2017
Homeostatic dynamics of PV-mediated cortical inhibition in the first days after auditory-nerve damage predict how well sound processing recovers.
Central Gain Restores Auditory Processing following Near-Complete Cochlear Denervation.
Neuron · 2016
After near-complete cochlear denervation, the cortex ramps up 'central gain' to restore basic sound detection, compensation that can overshoot into hyperactivity.