M. Charles Liberman
Eaton-Peabody Laboratories / Harvard Medical School
Cochlear nerve degeneration, synaptopathy, and 'hidden hearing loss'.
Papers (4)
Adding insult to injury: cochlear nerve degeneration after "temporary" noise-induced hearing loss.
The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009
The seminal finding: a 'temporary' noise-induced threshold shift that fully recovers still leaves permanent, silent damage, acute loss of nerve terminals and delayed degeneration of the cochlear nerve.
Cochlear neuropathy in human presbycusis: Confocal analysis of hidden hearing loss in post-mortem tissue.
Hearing research · 2015
Human evidence: post-mortem temporal bones from older adults with near-normal hair cell counts still showed cochlear nerve fiber loss, synaptopathy in human aging, not just mice.
Cochlear synaptopathy in acquired sensorineural hearing loss: Manifestations and mechanisms.
Hearing research · 2017
Review: well before hair cells die and thresholds rise, noise and aging silently sever the synapses between inner hair cells and the auditory nerve.
A National Cohort Study of Tinnitus and Hearing Loss in the Million Veteran Program.
Ear and hearing · 2026
National VA cohort of 267,395 veterans finds tinnitus in 47%, more common with traumatic brain injury, anxiety, or depression, and with earlier/steeper hearing loss than a civilian cohort.