Daniel B. Polley
Director, Eaton-Peabody Laboratories
Cortical plasticity, gain control, and perceptual disorders following cochlear injury.
Papers (5)
Cortical PV interneurons regulate loudness perception and sustainably reverse loudness hypersensitivity.
Neuron · 2026
40 Hz stimulation of cortical PV interneurons durably reverses loudness hypersensitivity in mice.
Cochlear neural degeneration disrupts hearing in background noise by increasing auditory cortex internal noise.
Neuron · 2021
Cochlear neural degeneration drives PV-linked cortical hyperactivity that predicts hearing-in-noise failures.
Fast-spiking GABA circuit dynamics in the auditory cortex predict recovery of sensory processing following peripheral nerve damage.
eLife · 2017
Homeostatic dynamics of PV-mediated cortical inhibition in the first days after auditory-nerve damage predict how well sound processing recovers.
Central Gain Restores Auditory Processing following Near-Complete Cochlear Denervation.
Neuron · 2016
After near-complete cochlear denervation, the cortex ramps up 'central gain' to restore basic sound detection, compensation that can overshoot into hyperactivity.
A National Cohort Study of Tinnitus and Hearing Loss in the Million Veteran Program.
Ear and hearing · 2026
National VA cohort of 267,395 veterans finds tinnitus in 47%, more common with traumatic brain injury, anxiety, or depression, and with earlier/steeper hearing loss than a civilian cohort.