Di Deng

Department of Physiology, University of Arizona

TNF-α-driven parvalbumin interneuron loss and auditory processing deficits.

Hypotheses

Treatments

Laboratory

Papers

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Laboratory1

Department of Physiology, College of Medicine

Hypotheses1

Central Neuroinflammation

Papers (1)

Diffusible Tumor Necrosis Factor-Alpha (TNF-α) Promotes Noise-Induced Parvalbumin-Positive (PV+) Neuron Loss and Auditory Processing Impairments.

Frontiers in neuroscience · 2020

Links neuroinflammation to the PV-interneuron hypothesis: elevated brain TNF-α plus noise causes loss of cortical parvalbumin interneurons and auditory processing deficits.

Animal study (in vivo)Mouse