Scientific KnowledgeAnimal study (in vivo)Mouse & ratAnimal study (in vivo)Mouse
Department of Physiology, College of Medicine
University of Arizona
Neuroinflammation, cortical plasticity and synaptic mechanisms of noise-induced tinnitus and hyperacusis.
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Researchers3
Hypotheses1
Papers (2)
Neuroinflammation mediates noise-induced synaptic imbalance and tinnitus in rodent models.
PLoS biology · 2019
The landmark causal study: noise-induced tinnitus is driven by TNF-α and microglial activation in the auditory cortex, and blocking either one prevents it in mice.
Diffusible Tumor Necrosis Factor-Alpha (TNF-α) Promotes Noise-Induced Parvalbumin-Positive (PV+) Neuron Loss and Auditory Processing Impairments.
Frontiers in neuroscience · 2020
Links neuroinflammation to the PV-interneuron hypothesis: elevated brain TNF-α plus noise causes loss of cortical parvalbumin interneurons and auditory processing deficits.