Scientific KnowledgeLooking for development status?Clinical stage, comparable drugs/devices, and estimated availability are tracked in the Therapy Pipeline.
AC102
Intratympanic synaptic-regeneration drug
Evidence level
No primary evidence catalogued yet
How it works
An intratympanic injection (AudioCure) that promotes regeneration of damaged cochlear ribbon synapses. In a 2025 preclinical study it restored inner-hair-cell ribbon synapses and reversed tinnitus-like behaviour in gerbils, direct animal evidence tying synaptic repair to tinnitus relief, and a therapeutic test of the Cochlear Synaptopathy hypothesis. Its human Phase 2 trial targets sudden sensorineural hearing loss, not tinnitus, so there is no human tinnitus efficacy data yet.
This describes the treatment concept as reported in the cited research: a scientific mechanism, not a guarantee of clinical availability.
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