40 Hz Cortical PVN Stimulation
Patterned gamma-frequency (40 Hz) stimulation of parvalbumin-expressing cortical interneurons
Preclinical: animal (in vivo) evidence, not yet studied in humans
How it works
A single bout of 40 Hz stimulation of cortical PV interneurons durably reduces auditory cortex gain and reverses loudness hypersensitivity in mice. A registered human trial (NCT07302373, Daniel Polley, Mass Eye and Ear) attempted to translate this to closed-loop sound therapy for tinnitus/hyperacusis, but it was withdrawn in 2025 after funding ended before any participant enrolled, so it remains not yet in active human clinical development.
This describes the treatment concept as reported in the cited research: a scientific mechanism, not a guarantee of clinical availability.
Evidence (1)
Cortical PV interneurons regulate loudness perception and sustainably reverse loudness hypersensitivity.
Neuron · 2026
40 Hz stimulation of cortical PV interneurons durably reverses loudness hypersensitivity in mice.