Scientific KnowledgeLooking for development status?Clinical stage, comparable drugs/devices, and estimated availability are tracked in the Therapy Pipeline. Animal study (in vivo)Mouse
40 Hz Cortical PVN Stimulation
Patterned gamma-frequency (40 Hz) stimulation of parvalbumin-expressing cortical interneurons
Evidence level
Preclinical: animal (in vivo) evidence, not yet studied in humans
How it works
A single bout of 40 Hz stimulation of cortical PV interneurons durably reduces auditory cortex gain and reverses loudness hypersensitivity in mice. Not yet in human clinical development.
This describes the treatment concept as reported in the cited research: a scientific mechanism, not a guarantee of clinical availability.
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Targets1
Evidence (1)
Cortical PV interneurons regulate loudness perception and sustainably reverse loudness hypersensitivity.
Neuron · 2026
40 Hz stimulation of cortical PV interneurons durably reverses loudness hypersensitivity in mice.