Susan E. Shore
Professor, Kresge Hearing Research Institute
Auditory-somatosensory integration in the dorsal cochlear nucleus and its role in tinnitus.
Papers (6)
Reversing Synchronized Brain Circuits Using Targeted Auditory-Somatosensory Stimulation to Treat Phantom Percepts: A Randomized Clinical Trial.
JAMA network open · 2023
Randomized clinical trial: bimodal auditory-somatosensory stimulation significantly reduced tinnitus loudness and severity.
Auditory-somatosensory bimodal stimulation desynchronizes brain circuitry to reduce tinnitus in guinea pigs and humans.
Science translational medicine · 2018
Foundational study: LTD-inducing bimodal stimulation desynchronizes DCN fusiform cells and reduced tinnitus in guinea pigs and a first-in-human trial.
Mechanisms of Noise-Induced Tinnitus: Insights from Cellular Studies.
Neuron · 2019
Review: only animals that develop tinnitus show distinct synchronized spontaneous firing in cochlear-nerve-recipient brainstem neurons, separating tinnitus from hearing loss.
Stimulus timing-dependent plasticity in dorsal cochlear nucleus is altered in tinnitus.
The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013
In tinnitus animals, the timing rules governing auditory, somatosensory (bimodal) plasticity in the DCN shift toward anti-Hebbian, the mechanistic rationale for timed bimodal therapy.
Increased Synchrony and Bursting of Dorsal Cochlear Nucleus Fusiform Cells Correlate with Tinnitus.
The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016
DCN fusiform cells fire with increased synchrony and bursting specifically in animals with behavioral tinnitus, a phantom-sound code emerging in the brainstem.
Ventral cochlear nucleus bushy cells encode hyperacusis in guinea pigs.
Scientific reports · 2020
A different DCN-region cell type, ventral cochlear nucleus bushy cells, encodes hyperacusis specifically, extending the DCN account beyond tinnitus alone.