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Shuang Li
Pittsburgh Hearing Research Center, University of Pittsburgh
Kv7.2/3 channel plasticity in dorsal cochlear nucleus hyperactivity.
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Laboratory1
Hypotheses1
Papers (2)
Pathogenic plasticity of Kv7.2/3 channel activity is essential for the induction of tinnitus.
Proceedings of the National Academy of Sciences of the United States of America · 2013
The seminal finding: reduced Kv7.2/3 channel activity in the dorsal cochlear nucleus is essential for tinnitus induction, and reversing it pharmacologically prevents tinnitus in mice.
Noise-induced plasticity of KCNQ2/3 and HCN channels underlies vulnerability and resilience to tinnitus.
eLife · 2015
Why do only some noise-exposed animals get tinnitus? Mice that fail to restore Kv7.2/3 channel activity within about a week develop tinnitus; those that do, become resilient.