Scientific KnowledgeAnimal study (in vivo)Mouse
JW
Jason W. Middleton
Pittsburgh Hearing Research Center, University of Pittsburgh
GABAergic inhibition and dorsal cochlear nucleus hyperactivity in tinnitus.
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Laboratory1
Hypotheses1
Papers (1)
Mice with behavioral evidence of tinnitus exhibit dorsal cochlear nucleus hyperactivity because of decreased GABAergic inhibition.
Proceedings of the National Academy of Sciences of the United States of America · 2011
Mice with confirmed behavioral tinnitus show dorsal cochlear nucleus hyperactivity driven by decreased GABAergic inhibition, a precursor finding to the Kv7.2/3 channel work.