Scientific KnowledgeHuman study (non-randomized / first-in-human)Guinea pig & HumanAnimal study (in vivo)Guinea pig
CW
Calvin Wu
Kresge Hearing Research Institute
Fusiform-cell synchrony and cellular mechanisms of noise-induced tinnitus in the DCN.
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Laboratory1
Hypotheses1
Papers (3)
Auditory-somatosensory bimodal stimulation desynchronizes brain circuitry to reduce tinnitus in guinea pigs and humans.
Science translational medicine · 2018
Foundational study: LTD-inducing bimodal stimulation desynchronizes DCN fusiform cells and reduced tinnitus in guinea pigs and a first-in-human trial.
Mechanisms of Noise-Induced Tinnitus: Insights from Cellular Studies.
Neuron · 2019
Review: only animals that develop tinnitus show distinct synchronized spontaneous firing in cochlear-nerve-recipient brainstem neurons, separating tinnitus from hearing loss.
ReviewN/A
Increased Synchrony and Bursting of Dorsal Cochlear Nucleus Fusiform Cells Correlate with Tinnitus.
The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016
DCN fusiform cells fire with increased synchrony and bursting specifically in animals with behavioral tinnitus, a phantom-sound code emerging in the brainstem.