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Bopanna I. Kalappa
Pittsburgh Hearing Research Center, University of Pittsburgh
KCNQ2/3 channel activators and tinnitus vulnerability/resilience.
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Laboratory1
Hypotheses1
Papers (2)
Noise-induced plasticity of KCNQ2/3 and HCN channels underlies vulnerability and resilience to tinnitus.
eLife · 2015
Why do only some noise-exposed animals get tinnitus? Mice that fail to restore Kv7.2/3 channel activity within about a week develop tinnitus; those that do, become resilient.
Potent KCNQ2/3-specific channel activator suppresses in vivo epileptic activity and prevents the development of tinnitus.
The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015
A more potent, more selective KCNQ2/3 activator (SF0034) prevented tinnitus development in mice, and was a safer anticonvulsant than the FDA-approved retigabine.