Scientific KnowledgeAnimal study (in vivo)Mouse
AV
Anastasios V. Tzingounis
Department of Physiology and Neurobiology, University of Connecticut
KCNQ channel pharmacology and neuronal excitability.
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Hypotheses1
Papers (1)
Potent KCNQ2/3-specific channel activator suppresses in vivo epileptic activity and prevents the development of tinnitus.
The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015
A more potent, more selective KCNQ2/3 activator (SF0034) prevented tinnitus development in mice, and was a safer anticonvulsant than the FDA-approved retigabine.