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AE
Albert Edge
Professor of Otolaryngology, Harvard Medical School / Mass Eye and Ear
Reprogramming supporting cells into cochlear hair cells via Notch/Wnt signaling to regenerate lost hearing.
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Laboratory1
Papers (2)
Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma.
Neuron · 2013
Pharmacological Notch inhibition converts cochlear supporting cells into new hair cells and partially restores hearing after noise trauma in mice.
Lgr5-positive supporting cells generate new hair cells in the postnatal cochlea.
Stem cell reports · 2014
Identifies Lgr5-expressing supporting cells as the specific source of newly generated hair cells after damage, and shows Notch inhibition boosts how many of them convert.