Scientific KnowledgeCase report (single patient, human)Human
Frontiers in neurology·2017·Londero A, ..., Noreña AJ
A Case of Acoustic Shock with Post-trauma Trigeminal-Autonomic Activation.
Human study (non-randomized / first-in-human)
Summary
A patient suffered an acoustic shock injury that caused no significant hearing loss but was followed by a cluster of chronic symptoms inside the ear (tinnitus, otalgia, tingling, tension, a red tympanic membrane) and outside it (blocked nose, neck/temporal pain). The authors propose these arise from a loop of middle-ear-muscle injury, peripheral inflammation, and activation/sensitization of the trigeminal nerve and autonomic nervous system with central feedback, a picture reminiscent of post-traumatic trigeminal-autonomic cephalalgia. It is the clinical illustration underpinning the tensor tympani, trigeminal model.
Key findings
- A real acoustic-shock case with normal hearing but the full symptom cluster in and around the ear.
- Signs point to middle-ear-muscle injury → peripheral inflammation → trigeminal and autonomic activation.
- Clinically resembles post-traumatic trigeminal-autonomic cephalalgia, linking ear symptoms to the trigeminal system.
- Single-patient observation, illustrative human evidence, not a controlled study.
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