Scientific KnowledgeHuman study (non-randomized / first-in-human)HumanHuman study (non-randomized / first-in-human)Human
VA National Center for Rehabilitative Auditory Research
VA Portland Health Care System / Oregon Health & Science University
Human physiological biomarkers of noise-induced and age-related cochlear synaptopathy.
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Researchers2
Hypotheses1
Papers (2)
Normative Ranges for Auditory Brainstem Response Wave I Amplitude: A Potential Diagnostic Indicator of Cochlear Deafferentation.
American journal of audiology · 2026
Sex-adjusted normative ABR Wave I amplitude ranges flag likely cochlear deafferentation in living patients, catching about half of a high-risk veteran sample.
Tinnitus and decreased sound tolerance in military Veterans: Relationship with cochlear deafferentation.
Hearing research · 2026
Veterans with normal hearing tests but constant tinnitus or reduced sound tolerance show weaker auditory nerve responses, a sign of cochlear deafferentation, while the middle ear muscle reflex turns out to be an unreliable marker of it.