Scientific KnowledgeAnimal study (in vivo)Rat
Center for Hearing and Deafness
University at Buffalo (SUNY)
Cochlear damage, central gain enhancement, tinnitus and hyperacusis.
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Researchers2
Hypotheses1
Papers (2)
Central gain control in tinnitus and hyperacusis.
Frontiers in neurology · 2014
The canonical review of central gain enhancement: why activity rises centrally even as the cochlea sends less, and how that produces tinnitus and hyperacusis.
ReviewN/A
Testing the Central Gain Model: Loudness Growth Correlates with Central Auditory Gain Enhancement in a Rodent Model of Hyperacusis.
Neuroscience · 2019
A direct test: within the same animals, drug-induced changes in loudness perception tracked changes in sound-evoked central activity, the link the gain model required.